If you’re exploring options to improve skin quality and address signs of aging, you may have heard of Hyperdilute RADIESSE® . Unlike traditional dermal fillers, this treatment focuses more on skin revitalization than adding volume. It’s quickly becoming a go-to solution for a smoother, firmer, and more youthful complexion—especially in areas where skin has thinned or lost elasticity.
In this guide, we’ll walk you through what Hyperdilute RADIESSE® is, how it works, who it’s best suited for, and what kind of results you can expect. We’ll also explore how it benefits individuals experiencing facial volume loss due to weight loss or GLP-1 medications.
What Is Hyperdilute RADIESSE® ?
Hyperdilute RADIESSE® is a formulation created by mixing RADIESSE® —a calcium-based dermal filler—with a sterile saline and anesthetic solution. This diluted version spreads more easily across larger areas of skin, stimulating natural collagen production without adding noticeable bulk or volume. The treatment is used more like a skin booster than a filler, gradually enhancing tone, texture, and firmness.
How It Works
The calcium microspheres in RADIESSE® act as a scaffold under the skin, encouraging your body to produce its own collagen and elastin. Over the weeks following treatment, this process leads to visibly improved skin quality—tighter, thicker, and smoother skin with better elasticity.
Most patients notice visible changes within a month, with full results developing over 2 to 3 months. Depending on the area treated and individual response, results can last up to a year or longer.
Benefits of Hyperdilute RADIESSE®
Skin Rejuvenation Without Bulk
This treatment is ideal for those who want natural-looking skin improvements without altering their facial shape. It tightens and improves skin tone subtly and progressively.
Treats Hard-to-Fix Areas
Hyperdilute RADIESSE® can be used in areas where the skin tends to thin with age and sun exposure, including:
- Neck and décolletage
- Upper arms
- Buttocks and thighs
- Jawline and lower face
Minimal Downtime
Most patients return to normal activities the same or next day. Side effects are usually limited to minor swelling, tenderness, or bruising.
Long-Term Results
Because the treatment stimulates your body’s own collagen production, the improvements last longer than typical hyaluronic acid fillers.
After Weight Loss or GLP-1 Medication
Massive weight loss, whether through lifestyle changes, bariatric surgery, or GLP-1 medications like Ozempic, can sometimes lead to a hollowed or gaunt facial appearance—sometimes referred to as “Ozempic face” or “GLP-1 face.” Hyperdilute RADIESSE® is an excellent option in these cases because it improves skin integrity rather than simply adding volume. It helps:
- Rebuild support in thinning areas of the face
- Smooth out crepey skin on the neck and chest
- Restore firmness and elasticity post-weight loss
For patients concerned about looking tired or deflated after achieving significant weight loss, this treatment can be a confidence-restoring solution.
GLP-1 Weight Loss Pre-Treatment with Radiesse
Radiesse isn’t just a solution after volume loss—it can be a proactive strategy before it happens. For patients beginning a GLP-1 weight loss journey, pre-treating with Radiesse helps reinforce the skin’s underlying structure. As you lose fat, this biostimulatory filler works beneath the surface to stimulate collagen and elastin production, helping maintain the face’s natural architecture.
This approach supports the skin during a time of rapid change, helping to prevent sagging and facial deflation before it starts. By beginning Radiesse treatments around the same time as weight loss, you give your skin the strength and elasticity it needs to age in reverse—not just shrink.
“Radiesse is an excellent way to proactively support your skin before beginning your GLP-1 weight loss journey. By stimulating the natural production of collagen and elastin, Radiesse helps reinforce the skin’s structural foundation as you lose weight. This strengthens facial support and helps prevent the sagging or volume loss that can accompany significant weight reduction. Pre-treating the skin with Radiesse offers a unique advantage—it begins working beneath the surface during the same period as your weight loss journey. This proactive approach helps preserve facial structure, preventing sagging or drooping as you lose weight. When timed together, these treatments can deliver optimal, balanced results.” — Amanda Olsen, PA-C lead injector at Specialists in Plastic Surgery in Raleigh, NC
Add GLP-1 Post Weight Loss Radiesse Treatment
If you’ve completed your weight loss journey and are noticing sagging or volume loss, Radiesse can play a critical role in restoring youthful structure and vitality. By stimulating the production of collagen types I and III, as well as elastin and key molecules like proteoglycans, Radiesse strengthens the skin from within.
It also enhances blood flow and tissue nourishment, promoting firmer, healthier-looking skin. This makes it a powerful post-weight-loss option to rebuild foundational support and bring back radiance and resilience to your appearance.
“If you’re noticing sagging or volume loss following weight loss, Radiesse can help restore and rejuvenate these areas. As a biostimulatory filler, Radiesse stimulates the natural production of collagen types I and III, elastin, proteoglycans, and enhances blood flow—promoting firmer, more radiant skin. This treatment helps rebuild structural support, improve elasticity, and nourish the skin for a healthy, revitalized glow.” — Amanda Olsen, PA-C
What to Expect During the Procedure
Consultation
You’ll meet with a provider to discuss your goals and assess the areas where your skin would benefit from collagen stimulation.
Treatment
The product is injected into the skin using fine needles or a cannula. The treatment usually takes 30-45 minutes, depending on the size of the area. A local anesthetic is typically included to keep discomfort minimal.
Recovery
You might notice some swelling or minor bruising, but this usually resolves quickly. Most patients can return to their regular routine within a day.
Traditional RADIESSE® vs. Hyperdilute RADIESSE®
While traditional RADIESSE® adds volume in areas like the cheeks or hands, Hyperdilute RADIESSE® is designed for skin rejuvenation. It’s not about creating fullness but enhancing the quality of your skin over time. Think of it as a skin-tightening serum in injectable form.
Complementary Treatments
To maximize results, your provider may suggest pairing Hyperdilute RADIESSE® with SkinPen® microneedling, MOXI™ laser treatments, or BOTOX® Cosmetic. These combinations can offer more dramatic and longer-lasting skin tightening and texture refinement.
Is Hyperdilute RADIESSE® Right for You?
Hyperdilute RADIESSE® is ideal for individuals:
- In their late 30s to 60s experiencing early to moderate skin laxity
- Recovering from significant weight loss or facial volume depletion
- Looking for gradual, natural-looking results
- Who want to avoid or delay surgery
A skilled injector can help determine if this treatment will align with your skin goals.
Frequently Asked Questions
1. How long does Hyperdilute RADIESSE® last?
Most results last 12-18 months, with improvements continuing as collagen production increases.
2. Is it painful?
Discomfort is minimal thanks to the inclusion of lidocaine in the formula. Most patients tolerate it very well.
3. How many treatments do I need?
Some patients see great results after one treatment, but a series of two to three spaced a few months apart may be recommended.
4. Can it be used on the face?
Yes. It’s often used on the lower face and jawline to improve skin firmness and tone.
5. What’s the downtime?
There is minimal downtime. Expect minor swelling or bruising for 24-48 hours.
Schedule Your RADIESSE® Consultation in Raleigh, NC
Hyperdilute RADIESSE® is a versatile, low-downtime option for anyone looking to enhance skin quality without going under the knife. Whether you’re looking to reverse early signs of aging, refresh your appearance post-weight loss, or target crepey skin on your neck and arms, this treatment offers powerful yet subtle rejuvenation.If you’re in Raleigh, NC, and ready to explore whether Hyperdilute RADIESSE® is right for you, schedule a consultation at Specialists in Plastic Surgery today.